Fenfluramine HCl
fenfluramine hydrochloride
CAS: 404-82-0
Molecular Formula: C12H17ClF3N
Fenfluramine HCl - Names and Identifiers
| Name | fenfluramine hydrochloride |
| Synonyms | Fenfluramine HCl fenfluramine hydrochloride FENFLURAMINE HYDROCHLORIDE MM(CRM STANDARD) n-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride (+)-n-ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride N-ETHYL-ALPHA-METHYL-M-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE N-ETHYL-ALPHA-METHYL-3-(TRIFLUOROMETHYL)PHENETHYLAMINE HYDROCHLORIDE |
| CAS | 404-82-0 |
| EINECS | 206-968-2 |
| InChI | InChI=1/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/p-1 |
Fenfluramine HCl - Physico-chemical Properties
| Molecular Formula | C12H17ClF3N |
| Molar Mass | 267.72 |
| Melting Point | 1660C |
| Boling Point | 108-112 °C(Press: 12 Torr) |
| Appearance | A solid |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White crystalline powder, odorless |
| Use | For appetite suppression drugs, can be used for simple obesity and suffering from diabetes, hypertension, cardiovascular disease, anxiety disorders in patients with obesity |
Fenfluramine HCl - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DA0295500 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in rabbit: 50mg/kg |
Fenfluramine HCl - Nature
Open Data Verified Data
white crystalline powder, odorless. Melting point 166 °c. Soluble in ethanol or chloroform, soluble in water, insoluble in ether.
Last Update：2024-01-02 23:10:35
Fenfluramine HCl - Preparation Method
Open Data Verified Data
- at 0 ° C., chlorosulfonic acid was added to a solution of trifluorotoluene and paraformaldehyde, and the mixture was stirred to obtain 3-chloromethyltrifluorotoluene. This was added to a solution of sodium cyanide in water and ethanol, and the reaction was processed to give 3-trifluoromethylbenzene acetonitrile. The compound was reacted with potassium hydroxide, water, and ethanol with heating. Ethanol was distilled off, neutralized with acid, and recrystallized to give 3-fluoromethylphenylacetic acid. A solution of methyl iodide in diethyl ether was added to the solution of diethyl ether and lithium under nitrogen and stirring, and the reaction was carried out. Then, the reaction was carried out by adding a solution of 3-fluoromethylphenylacetic acid in diethyl ether to a solution of the obtained compound and an excess of ethylamine in methanol. After standing, the reaction was carried out by adding potassium borohydride. Acidified to acidic, the aqueous layer was basified and extracted with dichloromethane. Dry hydrogen chloride was introduced into methylene chloride to be acidic, and the precipitated solid was recrystallized to obtain fenfluramine hydrochloride.
- or the reaction was carried out with magnesium turnings and an ether solution of M-bromotrifluorotoluene, followed by reflux. A solution of propylene oxide in diethyl ether was added dropwise with stirring, and the mixture was stirred. Into the mixture of concentrated hydrochloric acid and ice water, the compound is obtained by treatment, the compound is dissolved in ether, and the solution of sodium chromate is added dropwise under stirring to react, and the compound obtained by treatment and the methanol solution of excess ethylamine, after standing, potassium borohydride was added for reaction. Acidified to acidic, the aqueous layer was basified and extracted with dichloromethane. Dry hydrogen chloride was introduced into methylene chloride to be acidic, and the precipitated solid was recrystallized to obtain fenfluramine hydrochloride.
Last Update：2022-01-01 09:24:13
Fenfluramine HCl - Use
Open Data Verified Data
developed by Servier, Inc., launched in 1990. Amphetamine-type appetite suppressants. By reducing plasma triglycerides, increase free fatty acids, glycerol and ketone body levels, to reduce the body fat storage and synthesis, promote the decomposition of subcutaneous fat. In addition to simple obesity, can be used for patients with hypertension, diabetes, coronary heart disease and Anxiety of obese patients.
Last Update：2022-01-01 09:24:14
Fenfluramine HCl - Safety
Open Data Verified Data
mouse oral LD50:114 mg/kg.
Last Update：2022-01-01 09:24:14
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Fenfluramine HCl
对硝基苯偶氮水杨酸或钠盐
伊马替尼杂质甲基甲烷磺酸盐
2-(4,4-二氟环己-1-烯-1-基)硼酸频哪醇酯
Cyclopropanecarboxylic acid, 2-propyl-, methyl ester, trans- (9CI)
(R)-Auinuclidin-3-amine hydrochloride
Benzaldehyde, 4-methoxy-3-(4-methylphenylthiomethyl)-
反式对甲氧基-Β-硝基苯乙烯
(S)-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester
2-[bis[4-(phosphonooxy)phenyl]methyl]benzoic acid, compound with pyridine (1:1)
对硝基苯偶氮水杨酸或钠盐
伊马替尼杂质甲基甲烷磺酸盐
2-(4,4-二氟环己-1-烯-1-基)硼酸频哪醇酯
Cyclopropanecarboxylic acid, 2-propyl-, methyl ester, trans- (9CI)
(R)-Auinuclidin-3-amine hydrochloride
Benzaldehyde, 4-methoxy-3-(4-methylphenylthiomethyl)-
反式对甲氧基-Β-硝基苯乙烯
(S)-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester
2-[bis[4-(phosphonooxy)phenyl]methyl]benzoic acid, compound with pyridine (1:1)